Evaluation of cardiac effects of the new antineoplastic drug - dimethoxybenfluron - in the rabbit

Title:

Evaluation of cardiac effects of the new antineoplastic drug - dimethoxybenfluron - in the rabbit

Creator:

Jarmila Macháčková, Michaela Adamcová, Yvona Mazurová, Radomír Hrdina, and Milan Nobilis

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:11792177-a96e-4675-b987-312ecdc6aead
uuid:11792177-a96e-4675-b987-312ecdc6aead
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, kardiomyopatie, cardiomyopathy, cardiac troponin T, daunorubicin, dimethosybenfluron, antineoplastic drugs, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Cardiotoxicity ranks among the most serious adverse effects of some cytostatics. The cardiac effects of repeated i.v. administration of a new antineoplastic agent, dimethoxybenfluron (once a week, 10 administrations), were investigated in rabbits with respect to cardiac function and the release of cardiac troponin T (cTnT). Different doses of dimethoxybenfluron were administered to two groups of animals (12 mg/kg; n = 7 and 24 mg/kg; n = 6) and compared with either a control group (saline 1 ml/kg; n = 6) or a group with experimentally induced cardiomyopathy (daunorubicin 50 mg/m2; n = 13). In daunorubicin-induced cardiomyopathy, cTnT levels in animals with premature deaths were significantly higher (0.31±0.11 mg/l) in comparison with the surviving animals (0.04±0.03 mg/l). However, cardiac TnT levels after the administration of dimethoxybenfluron in both doses were within the physiological range (lower than 0.1 mg/l) during the whole experiment as it was in the control group. The lack of cardiotoxicity of this new antineoplastic drug was supported by the absence of alterations in PEP:LVET ratio, left ventricle dP/dtmax or histological heart examination as well as by the fact that no premature death of animals occurred following repeated administration of dimethoxybenfluron. It is possible to conclude that no signs of cardiotoxicity were observed following repeated i.v. administration of dimethoxybenfluron., J. Macháčková, M. Adamcová, Y. Mazurová, R. Hrdina, M. Nobilis., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:5

Harvested from:

CDK

Metadata only:

false