Proconvulsant action of two GABAb receptor antagonists is age-dependent

Title:

Proconvulsant action of two GABAb receptor antagonists is age-dependent

Creator:

Pavel Mareš

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:110e6b1d-ff93-4623-9c33-d3056afde645
uuid:110e6b1d-ff93-4623-9c33-d3056afde645

Subject:

Fyziologie člověka a srovnávací fyziologie, elektroencefalogramy, electroencephalograms, GABAb receptor antagonists, cortical afterdischarges, immature rats, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Antagonists of GABA B receptors are expected to have proconvulsant acti on also in developing brain. Two antagonists (CGP55845 and CGP46381) were tested in a model of cortical epileptic afterdischarges (ADs) in 12-, 18- and 25-day-old rat pups with implanted electrodes. CGP55845 was dissolved in dimethylsulfoxide and the results demonstrated marked proconvulsant action of this solvent which masked possible action of the antagonist. Water soluble antagonist CGP46381 led to marked potentiation of ADs in 12-day-old animals, its action decreased with age, it was negligible in 25-day-old rats. Our results demonstrated important inhibitory role of GABA B receptors at very early stages of maturation., P. Mareš., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2013 Volume:62 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false