Loss of body weight is accompanying cellular brain edema induced by water intoxication in the rat

Title:

Loss of body weight is accompanying cellular brain edema induced by water intoxication in the rat

Creator:

Kozler, P. , Marešová, D., and Pokorný, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:10da2aef-6aac-4b1d-82f7-f35c07bc6cc8
uuid:10da2aef-6aac-4b1d-82f7-f35c07bc6cc8
doi:10.33549/physiolres.934077

Subject:

Weight loss, Water intoxication, and Brain edema

Type:

model:article and TEXT

Format:

bez média and svazek

Description:

Induction of cellular cerebral edema (CE) was achieved by a standard method of water intoxication which consisted of fractionated intraperitoneal administration of distilled water (DW) together with the injection of desmopressin (DP). Using metabolic cage, fluid and food balance was studied in two groups of eight animals: group C – control; group CE – cellular edema induced by water intoxication. For each rat the intake (food pellets and water) and excretion (solid excrements and urine) were recorded for 48 h together with the initial and final body weight. CE animals consumed significantly less food, drank less water and eliminated the smallest amount of excrements. The induction of cellular cerebral edema was accompanied with a significant loss of body weight (representing on average 13 % of the initial values) mainly due to a reduction of food intake. This phenomenon has not yet been reported.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Coverage:

321-324

Source:

Physiological research | 2019 Volume:68 | Number:2

Harvested from:

CDK

Metadata only:

false