Arterial pH and blood gas values in rats under three types of general anesthesia: a chronobiological study

Title:

Arterial pH and blood gas values in rats under three types of general anesthesia: a chronobiological study

Creator:

Pavol Švorc and Darina Petrášová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:0c067336-4c67-4797-9e32-2e8ad3d93603
uuid:0c067336-4c67-4797-9e32-2e8ad3d93603
issn:0862-8408

Subject:

chronobiologie, anestezie, chronobiology, anesthesia, pH, blood gases, rats, 14, and 612

Type:

model:article and TEXT

Format:

print, bez média, and svazek

Description:

The aim of study was to review the status of arterial pH, pO2 and pCO2 under general anesthesias in dependence on the light-dark (LD) cycle in spontaneously breathing rats. The experiments were performed using three- to four-month-old pentobarbital(P)-, ketamine/xylazine(K/X)- and zoletil(Z)-anesthetized female Wistar rats after a four-week adaptation to an LD cycle (12 h light:12 h dark). The animals were divided into three experimental groups according to the anesthetic agent used: P (light n=11; dark n=8); K/X (light n=13; dark n=11); and Z (light n=18; dark n=26). pH and blood gases from arterial blood were analyzed. In P anesthesia, LD differences in pH, pO2, and pCO2 were eliminated. In K/X anesthesia, parameters showed significant LD differences. In Z anesthesia, LD differences were detected for pH and pO2 only. Acidosis, hypoxia, and hypercapnia have been reported for all types of anesthesia during the light period. In the dark period, except for P anesthesia, the environment was more stable and values fluctuated within normal ranges. From a chronobiological perspective, P anesthesia was not the most appropriate type of anesthesia in these rat experiments. It eliminated LD differences, and also produced a more acidic environment and more pronounced hypercapnia than K/X and Z anesthesias., P. Svorc, D. Petrášová, P. Svorc Jr., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2018 Volume:67 | Number:5

Harvested from:

CDK

Metadata only:

false