Sedative effects of intranasal oxytocin in rabbits and rhesus monkeys

Title:

Sedative effects of intranasal oxytocin in rabbits and rhesus monkeys

Creator:

Hess, L., Votava, M., Málek, J., Kurzová, A., and Slíva, J.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:0a22f167-507e-45ba-a7a7-281f20a11d1c
uuid:0a22f167-507e-45ba-a7a7-281f20a11d1c

Subject:

Oxytocin, Anxiety, Sedation, Monkeys, and Rabbits

Type:

article, model:article, and TEXT

Description:

Oxytocin is a hormone therapeutically used mainly for its peripheral effects during pregnancy in the uterus and breasts. However, additional central effects, i.e. anxiolytic effect, decreased level of social stress and increased empathy have been also observed. Hence, the aim of our study was to evaluate if nasal oxytocin can be used as anxiolytic substance in rhesus monkeys (n=20) and rabbits (n=20). Simultaneously, mean arterial blood pressure, arterial oxygen saturation of hemoglobin and pulse rate were monitored in all the evaluated animals. While rabbits lost righting reflex, monkeys developed a dose-dependent loss of aggressiveness and/or anxiety as evaluated by behavioral methods (aggressive behavior was classified as non-sedated ‒ sedated ‒ strongly sedated)

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2016 Volume:65 | Number:Suppl 4

Harvested from:

CDK

Metadata only:

false