Spatial navigation: implications for animal models, drug development and human studies

Title:

Spatial navigation: implications for animal models, drug development and human studies

Creator:

Aleš Stuchlík, Kubik, S., Kamil Vlček, and Karel Valeš

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:06d097b7-6815-40e0-af5a-29f31aa57b7a
uuid:06d097b7-6815-40e0-af5a-29f31aa57b7a

Subject:

Fyziologie člověka a srovnávací fyziologie, paměť, učení, navigace, mozek, neurony, memory, learning, navigation, brain, neurons, spatial representation, moving environments, rats, animal models, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

Spatial navigation and memory is considered to be a part of the declarative memory system and it is widely used as an animal model of human declarative me mory. However, spatial tests typically involve only static settings, despite the dynamic nature of the real world. Animals, as well as people constantly need to interact with moving objects, other subjects or even with entire moving environments (flowing water, running stairway). Therefore, we design novel spatial tests in dynamic environments to study brain mechanisms of spatial processing in more natural settings with an interdisciplinary approach including neuropharmacology. We also translate data from neuropharmacological studies and animal models into development of novel therapeutic approaches to neuropsychiatric disorders and more sensitive screening tests for impairments of memory, thought, and behavior., A. Stuchlik ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2014 Volume:63 | Number:Suppl 1

Harvested from:

CDK

Metadata only:

false