Plasma procalcitonin in parients with ileus. Relations to other inflammatory parameters

Title:

Plasma procalcitonin in parients with ileus. Relations to other inflammatory parameters

Creator:

Pavel Maruna, Roman Fraško, and Robert Gürlich

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:02f9bb8e-11b8-40b7-a5be-674e6dc92e9b
uuid:02f9bb8e-11b8-40b7-a5be-674e6dc92e9b
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, patologická fyziologie, střevní neprůchodnost, prokalcitocin, pathological physiology, intestinal obstructions, procalcitocin, C-reactive protein, interleukin-6, tumor necrosis factor, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

Plasma procalcitonin (PCT) is a highly specific marker for the diagnosis of bacterial infections and sepsis. PCT levels are usually low in viral infections, chronic inflammation or postsurgical states. The purpose of this study was to characterize PCT plasma levels in patients with various types of ileus at preoperative stage, where the other inducing factors suchas a surgical stress are excluded. The prospective study was performed on 54 patients admitted to in-patient surgical department with a proven diagnosis of ileus. Patients were divided to three groups – obstructive, vascular and paralytic ileus. Plasma levels of PCT (Kryptor analysis), TNFα, IL-1β, IL-6, cortisol (ELISA) and CRP (Kryptor ultrasensitive analysis) were estimated before any invasive procedure was realized. We demonstrated significant elevation of PCT in both obstructive ileus in adhesions and vascular ileus compared with healthy subjects (p<0.01). PCT levels were not elevated in paralytic ileus. The regression coefficient was the highest for PCT and CRP (r=0.78, p<0.01), for TNFα and IL-8 (r=0.76, p<0.01) in vascular ileus. There was no significant correlation between PCT and other inflammatory parameters. The different types of ileus induce an elevation of plasma PCT levels and PCT shows itself as an acute phase reactant. The highest PCT concentrations were presented in patients with vascular ileus, whereas paralytic ileus revealed similar cytokine and PCT pattern as in healthy subjects. Plasma PCT estimation extended to a measurement of CRP and IL-6 may become a useful complementary examination for diagnostics of acute abdomen in patients., P. Maruna, R. Fraško, R. Gürlich., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2008 Volume:57 | Number:3

Harvested from:

CDK

Metadata only:

false