Detection of microembolic signals in the common carotid artery using doppler sonography in the porcine model of acute heart failure treated by veno-arterial extracorporeal membrane oxygenation

Title:

Detection of microembolic signals in the common carotid artery using doppler sonography in the porcine model of acute heart failure treated by veno-arterial extracorporeal membrane oxygenation

Creator:

Janák, D., Hála, P., Mlček, M., Popková, M., Lacko, S., Kudlička, J., and Kittnar, O.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:02ed1463-31bb-4faa-bf64-c8e21922650c
uuid:02ed1463-31bb-4faa-bf64-c8e21922650c

Subject:

extracorporeal membrane oxygenation, microembolic signal, signal, and porcine model

Type:

article, model:article, and TEXT

Description:

Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a method used for the treatment most severe cases of decompensated heart failure. The purpose of this study was to evaluate the risk of the formation of microembolisms during VA-ECMO-based therapy. Heart failure was induced with simultaneous detection of microembolisms and the measurement of blood flow rate in the common carotid artery (CCA) without VA-ECMO (0 l/min) and at the VA-ECMO blood flow rate of 1, 2, 3 and 4 l/min. If embolisms for VA-ECMO 0 l/min and the individual regimes for VA-ECMO 1, 2, 3, 4 l/min are compared, a higher VA-ECMO flow rate is accompanied by a higher number of microembolisms. The final microembolism value at 16 min was for the VA-ECMO flow rate of 0 l/min 0.0 (0, 1), VA-ECMO l/min 7.5 (4, 19), VA-ECMO 2 l/min 12.5 (4, 26), VA-ECMO 3 l/min, 21.0 (18, 57) and VA-ECMO 4 l/min, 27.5 (21, 64). Such a comparison is statistically significant if VA-ECMO 0 vs. 4 l/min p<0.0001, 0 vs. 3 l/min p<0.01 and 1 vs. 4 l/min p<0.01 are compared. The results confirm that high VA-ECMO flow rates pose a risk with regards to the formation of a significantly higher number of microemboli in the blood circulation and that an increase in blood flow rates in the CCA corresponds to changes in the VA-ECMO flow rates.

Language:

English

Rights:

http://creativecommons.org/publicdomain/mark/1.0/
policy:public

Source:

Physiological research | 2017 Volume:66 | Number:Suppl 4

Harvested from:

CDK

Metadata only:

false