Effect of ethanol on tracheal potassium channels reconstituted into bilayer lipid membranes

Title:

Effect of ethanol on tracheal potassium channels reconstituted into bilayer lipid membranes

Creator:

Komínková, V., Magová, M., Mojžišová, A., Máleková, Ľ., and Ondriaš, K.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:01ff4cdc-8ec6-4bac-bac5-d32a97743ad3
uuid:01ff4cdc-8ec6-4bac-bac5-d32a97743ad3
issn:0862-8408

Subject:

Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, potassium channel, trachea - ethanol, bilayer lipid membrane, bronchodilation, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print, bez média, and svazek

Description:

We examined the effect of ethanol on single potassium channels derived from plasma membranes of bovine tracheal smooth muscles. The observed potassium channels had a conductance of 296±31 pS (mean ± S.D.) in symmetrical 250 mmol/l KCl solutions, and exhibited a voltage- and Ca2+-dependence similar to BKCa channels. Ethanol at 50, 100 and 200 mM concentrations increased the probability of open potassium channels to 112±5, 127±7 and 121±13% (mean ± S.E.M.), respectively. It is suggested that increased activity of the BKCa channels by ethanol hyperpolarizes the plasma membrane and thus may contribute to relaxation of tracheal smooth muscle., V. Komínková, M. Magová, A. Mojžišová, Ľ. Máleková, K. Ondriaš., and Obsahuje bibliografii

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2001 Volume:50 | Number:5

Harvested from:

CDK

Metadata only:

false