Anticlastogenic effect of S-2-(3-aminopropyIamino) ethylphosphorothioic acid against X-rays in mice

Title:

Anticlastogenic effect of S-2-(3-aminopropyIamino) ethylphosphorothioic acid against X-rays in mice

Creator:

Mazur, L.

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:00ee75a6-b792-4b21-b85e-040fe930adf6
uuid:00ee75a6-b792-4b21-b85e-040fe930adf6

Subject:

X-rays, WR-2721, mouse bone marrow, and in vivo micronucleus test

Type:

article, model:article, and TEXT

Description:

The anticlastogenic effect of the aminothiol agent S-2-(3-aminopropylamino) ethylphosphorothioic acid (WR-2721) against X-rays was assessed by in vivo mouse micronuclcus assay. The frequency of micronuclei in the bone marrow of adult male Swiss mice treated with WR-2721, at a radioprotective dose of 200 mg/kg or 400 mg/kg body weight, 15 or 30 min before exposure to a sublcthal dose of 6 Gy X-rays, was determined 24 h after X-irradiation. The protective effect of WR-2721 against X-ray- induced clastogenicity was shown in the erythropoietic system. WR-2721 administration prior to X-ray exposure was found to decrease the number of micronucleated polychromatic erythrocytes elevated by X-irradiation. The protection against the clastogenic activity of X-rays by WR-2721 was least evident when the thiol had been administered in the lower dose of 200 mg/kg body weight, 15 min before X-irradiation, and was most effective when giving WR-2721 in the higher dose, 400 mg/kg body weight, 30 min prior to exposure of mice to X-rays. Thus, the radioprotective effect of S-2-(3-aminopropylamino) ethylphosphorothioic acid against genotoxicity by X-rays appeared to depend on the dose given and the time intervals between WR-2721 administration and X-irradiation of mice. A novel clinical application of the drug could be in its use to protect against radiation-thcrapy-induccd genotoxic damage to normal cells.

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 1996 Volume:45 | Number:1

Harvested from:

CDK

Metadata only:

false