Gender specific influence of fish oil or atorvastatin on functional properties of renal Na, K-ATPase in healthy wistar and hypertriglyceridemic rats

Title:

Gender specific influence of fish oil or atorvastatin on functional properties of renal Na, K-ATPase in healthy wistar and hypertriglyceridemic rats

Creator:

Vrbjar, N., Mézešová, L., Veronika Javorková, Vlkovičová, J., Mitašíková, M., Katarína Dlugošová, Ľudmila Okruhlicová, and Narcisa Tribulová

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:00743bf5-7f20-441c-a30d-2cbb7fc76962
uuid:00743bf5-7f20-441c-a30d-2cbb7fc76962

Subject:

Fyziologie člověka a srovnávací fyziologie, pohlavní rozdíly, sex differences, sodium pump, kidney, hereditary hypertriglyceridemia, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

For better understanding of pathophysiological processes leading to increased retention of sodium as a consequence of hyperlipidemia, the properties of renal Na,K-ATPase, a key enzyme involved in maintaining sodium homeostasis in the organism, were studied. Enzyme kinetics of renal Na,K-ATPase were used for characterization of ATP- and Na+-binding sites after administration of fish oil (FO) (30 mg · day-1) or atorvastatin (0.5 mg·100 g-1 day-1) to healthy Wistar rats and rats with hereditary hypertriglyceridemia of both genders. Untreated healthy Wistar and also hypertriglyceridemic female rats revealed higher Na,K-ATPase activity as compared to respective untreated male groups. Hypertriglyceridemia itself was accompanied with higher Na,K-ATPase activity in both genders. Fish oil improved the enzyme affinity to ATP and Na+, as indicated by lowered values of K m and K Na in Wistar female rats. In Wistar male rats FO deteriorated the enzyme in the vicinity of the Na+-binding site as revealed from the increased K Na value. In hypertriglyceridemic rats FO induced a significant effect only in females in the vicinity of the sodium binding sites resulting in improved affinity as documented by the lower value of KNa. Atorvastatin aggravated the properties of Na,K-ATPase in both genders of Wistar rats. In hypertriglyceridemic rats protection of Na,K-ATPase was observed, but this effect was bound to females only. Both treatments protected renal Na,K-ATPase in a gender specific mode, resulting probably in improved extrusion of excessive intracellular sodium out of the cell affecting thus the retention of sodium in hHTG females only., N. Vrbjar ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2011 Volume:60 | Number:6

Harvested from:

CDK

Metadata only:

false