Search

Start Over Subject komplikace těhotenství--krev

1. Assessment of placental and maternal stress responses in patients with pregnancy related complications via monitoring of heat shock protein mRNA levels

Creator:
Hromadníková, Ilona, Dvořáková, Lenka, Kotlabová, Kateřina, Kestlerová, A., Hympánová, Lucie, Novotná, Veronika, Doucha, Jindřich, and Krofta, Ladislav
Format:
electronic, electronic resource, remote, and elektronický zdroj
Type:
model:article, article, Text, abstrakt z konference, and TEXT
Subject:
komplikace těhotenství--krev, stres fyziologický, proteiny tepelného šoku--analýza--krev, messenger RNA--analýza--krev, ženské pohlaví, lidé, and těhotenství
Language:
Czech and English
Description:
Ilona Hromadnikova, Lenka Dvorakova, Katerina Kotlabova, Andrea Kestlerova, Lucie Hympanova, Veronika Novotna, Jindrich Doucha, Ladislav Krofta and Literatura
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

2. Hyperleptinemia as a prognostic factor for preeclampsia: a cohort study

Creator:
Mendieta Zerón, Hugo, García Solorio, Verónica Jackeline, Nava Díaz, Pamela Montserrat, Garduño Alanís, Adriana, Santillán Benítez, Jonnathan Guadalupe, Domínguez García, Victoria, Escobar Briones, Carolina, and Denova Gutiérrez, Edgar
Format:
print, text, and regular print
Type:
model:article, article, Text, časopisecké články, práce podpořená grantem, and TEXT
Subject:
dospělí, index tělesné hmotnosti, gestační diabetes--krev, ženské pohlaví, lidé, leptin--krev, obezita--komplikace, nadváha--krev, preeklampsie--krev--etiologie, těhotenství, komplikace těhotenství--krev, prognóza, rizikové faktory, and senzitivita a specificita
Language:
English
Description:
INTRODUCTION: Leptin is an adipokine which has a direct relationship to obesity. Our aim was to measure this hormone in pregnant women at three months intervals throughout their pregnancies to determine the serum value of those who developed preeclampsia. MATERIAL AND METHODS: We followed 19 women (median age 24.8 +/- 5.7 years) with pre-gestational Body Mass Index (BMI) less than 25 kg/m2, 21 (median age 26.1 +/- 4.6 years) with BMI higher than 25 kg/m2 and 16 (median age 30.9 +/- 5.8 years) with Gestational Diabetes Mellitus (GDM) (median age 30.9 +/- 5.8 years), recruited in the 1st trimester of pregnancy. Serum levels of leptin were measured with radioimmunoassay (RIA) technique. RESULTS: In the first trimester of pregnancy leptin levels showed statistically significant differences between normal weight and overweight-obese women (p < 0.001), diabetic women (p < 0.05) and the subgroup of preeclamptic women (p < 0.001). For those women with PGBMI > or = 40 kg/m2 and leptin > or = 40 ng/ml in the second trimester, the Odds Ratio (OR) to develop preeclampsia was of 47.95% CI (4.1-527.2). Analyzing leptin values with ROC curves, the greatest area under the curve (AUC) was for leptin in the second trimester (0.773, CI: 0.634-0.911). CONCLUSION: Women with morbid obesity (BMI > or = 40 kg/m2) had significantly higher levels of serum leptin (p < 0.01) and a value of 40 ng/ml of this hormone seems to be predictive of developing preeclampsia in this group of patients. and H. Mendieta Zerón, VJ. García Solorio, PM. Nava Díaz, A. Garduño Alanís, JG. Santillán Benítez, V. Domínguez García, C. Escobar Briones, E. Denova Gutiérrez
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public