Index, Na přídeští je fialové hranaté razítko Ústav pro zdravotnickou dokumentaci, na rubu titulního listu červené hranaté razítko Státní ústav pro zdravotnickou dokumentační a knihovnickou službu, Jedná se o tisk na ručním papíře, svázaný do celopergamenové vazby s lepenkovými deskami Kniha byla v roce 2004 restaurována K Opatovou Kniha je uložena v ochranném pouzdře z nekyselé lepenky, Restaurování 2004 Desinfekce, oprava oprava původní vazby, and Digitalizace 2004 AiP Beroun
Hepcidin, a key regulator of iron metabolism, plays a crucial role in the pathogenesis of anemia of chronic disease. Although it is produced mainly in the liver, its recently described expression in adipose tissue has been shown to be enhanced in massive obesity due to chronic low-grade inflammation. Our objective was to study the changes in hepcidin expression in adipose tissue during acute-phase reaction. We measured hepcidin mRNA expression from isolated subcutaneous and epicardial adipose tissue at the beginning and at the end of the surgery. The expression of mRNAs for hepcidin and other iron-related genes (transferrin receptor 1, divalent metal transporter 1, ferritin, ferroportin) were measured by real-time RT-PCR. Hepcidin expression significantly increased at the end of the surgery in subcutaneous but not in epicardial adipose tissue. Apart from the increased levels of cytokines, the parameters of iron metabolism showed typical inflammation-induced changes. We suggest that acute inflammatory changes could affect the regulation of hepcidin expression in subcutaneous adipose tissue and thus possibly contribute to inflammation-induced systemic changes of iron metabolism., M. Vokurka ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy