Number of results to display per page
Search Results
29022. Permanent depression of plasma cGMP during long-term space flight
- Creator:
- Rössler, A., Noskov, V., László, Z., Polyakow, V. V., and Helmut Hinghofer-Szalkay
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Fyziologie člověka a srovnávací fyziologie, fyziologie, physiology, Long-duration space flight, head-down tilt, cyclic guanosine monophosphate, atrial natriuretic peptide, bed rest, 14, and 612
- Language:
- English
- Description:
- The purpose of this study was to investigate plasma concentrations of cyclic guanosine monophosphate (cGMP) and atrial natriuretic peptide (ANP) during and after real and simulated space flight. Venous blood was obtained 3 min after the beginning and 2 min after the lower body negative pressure maneuver in two cosmonauts preflight (supine), inflight, and postflight (supine) and in five other subjects before, at the end, and 4 days after a 5-day head-down tilt (-6°) bed rest. In cosmonaut 1 (10 days in space), plasma cGMP fell from preflight 4.3 to 1.4 nM on flight day 6, and was 3.0 nM on the fourth day after landing. In cosmonaut 2 (438 days in space), it fell from preflight 4.9 to 0.5 nM on on flight day 3, and stayed <0.1 nM with 5, 9, and 14 months in space, as well as on the fourth day after landing. Three months after the flight his plasma cGMP was back to normal (6.3 nM). Cosmonaut 2 also displayed relatively low inflight ANP values but returned to preflight level immediately after landing. In a ground-based simulation on five other persons, supine plasma cGMP was reduced by an average of 30 % within 5 days of 6° head-down tilt bed rest. The data consistently demonstrate lowered plasma cGMP with real and simulated weightlessness, and a complete disappearance of cGMP from plasma during, and shortly after long-duration space flight., A. Rössler, V. Noskov, Z. László, V.V. Polyakow, H. G. Hinghofer-Szalkay., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
29023. Permanent GPS station in Ksiaz geodynamic laboratory for supporting investigations of neo-tectonic motions in the Ksiaz Massif
- Creator:
- Zdunek, Ryszard
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Geologie. Meteorologie. Klimatologie, tektonika, GPS (navigační systém), geotectonics, GPS (navigation system), GPS measurements, station coordinates time series, recent tectonic movements, crustal movements, tidal and non-tidal signals, 7, and 551
- Language:
- English
- Description:
- In Autumn 2010 a new permanent GPS station started observati ons intended to investigate the episodic displacements o f rocks in the Książ Massif, where the Geodynamic Laboratory (LG) is situated. These investigations are being made for common interpretation with water-tubes and horizontal pendulums tiltmeters registering large (one order of magnitude greate r than the tidal effects) non-periodic geodynamic signals. The studies conducted as up to date excluded instrumental and loading effects as potential reasons of those signals. The construction of water-tube tiltmeters and their measuring principles allowed to state that the strong non-tidal signals have a geodynamic nature. To support investig ation of this problem, different analysis of the GPS data are performed in appropriate scales and applying various processing methods. The applied methods refer to selected reference GPS stations in Poland and their neighbors and are aimed at reduction of disturbance effects of geophysical origin such as tectonic activity, post-glacial rebound, anthropogenic effects, etc., Ryszard Zdunek., and Obsahuje bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
29024. Permeability and porosity of rocks and their relationship based on laboratory testing
- Creator:
- Šperl, Jan and Jiřina Trčková
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Geologie. Meteorologie. Klimatologie, propustnost materiálů, pórovitost, permeability, porosity, rock samples, 7, and 551
- Language:
- English
- Description:
- Physical mass properties of various types of rocks were ascertained, and their relationships are discu ssed in this article. Basedon water permeability and mercury intrusion porosimetry methods, conductivity coefficient, porosity, and pore size distribution were determined. Furthermore, bulk and particle densities of rocks we re determined. All laboratory tests were carried out according to Czech versi on of the Technical specif ication CEN ISO/TS 17892-11:2004. The above-mentioned specification has the status of the Czech standard (ČSN, CEN). Permeability and porosity are in close relation, and it could be assumed that its relationship is linear, i.e., with increasing porosity, permeability increases as well. This relationship is influenced by other rock properties, such as the amount of open and closed pores with in the rock sample, size, and distribution of pores or mineral admixtures. From this point of view, it is necessary to study these physical properties of rocks as well, because this enables an overall analysis of rocks and its possible use for engineering constructions, Jan Šperl and Jiřina Trčková., and Obsahuje bibliografické odkazy
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
29025. Permeability and volumetric changes in coal under different test environment
- Creator:
- Aziz, Naj, Ren, Ting, Nemcik, Jan, and Zhang, Lei
- Format:
- print, bez média, and svazek
- Type:
- article, články, model:article, and TEXT
- Subject:
- Geologie. Meteorologie. Klimatologie, těžba uhlí, doly, coal mining, mines, coal mine gas, coal permeability, volumetric changes, 7, and 551
- Language:
- English
- Description:
- Permeability refers to the ability of coal to transmit gas when a pressure or concentration gradient exists across it. The permeability of coal is dependent upon factors that include effective stress, gas pressure, water content, disturbance associated with drilling and matrix swelling/shrinkage due to adsorption/desorption. A programme of laboratory tests were conducted on coal samples from the Bulli seam for evaluating the permeability and drainability of coal. Two different types of permeability apparatus were used in this study. The methods of permeability testing of coal under different triaxial conditions are discussed. Permeability testing of the Bulli seam coal with N2 is described. The laboratory test results were found to be in agreement with the calculated permeability values, Naj Aziz, Ting Ren, Jan Nemcik and Lei Zhang., and Obsahuje bibliografii
- Rights:
- http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public
29026. Pernštejn. A moravian medieval castle /
- Publisher:
- Památkový ústav v Brně,
- Subject:
- hrady, hrady, hradiště, zámky, tvrze, dvory, and české země 1306-1526
- Language:
- English
- Rights:
- unknown
29027. Perona-Malik equation: Properties of explicit finite volume scheme
- Creator:
- Handlovičová, Angela
- Format:
- bez média and svazek
- Type:
- model:article and TEXT
- Subject:
- Perona-Malik equation, finite volume method, consistency, and stability monotonicity property
- Language:
- English
- Description:
- The Perona-Malik nonlinear parabolic problem, which is widely used in image processing, is investigated in this paper from the numerical point of view. An explicit finite volume numerical scheme for this problem is presented and consistency property is proved.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
29028. Peroperační detekce sentinelové uzliny při resekci pro karcinom kolon – předběžné výsledky
- Creator:
- Cagaš, Jan, Čapov, Ivan, Vlček, Petr, Korbička, Jiří, Veverková, Lenka, Hermanová, Markéta, and Tichý, Michal
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, práce podpořená grantem, srovnávací studie, and TEXT
- Subject:
- lidé, mužské pohlaví, ženské pohlaví, nádory tračníku--chirurgie--patologie, karcinom--chirurgie--patologie, peroperační doba, sentinelová lymfatická uzlina - biopsie, lymfatické metastázy--patologie, senzitivita a specificita, lymfadenektomie, lymfatické uzliny--chirurgie--patologie, barvící látky--diagnostické užití, rosanilínová barviva--diagnostické užití, staging nádorů, and Patentblau
- Language:
- Czech and English
- Description:
- Úvod: Cílem práce je porovnat výsledky peroperační detekce sentinelové uzliny při operacích pro karcinom kolon a zjistit počet uzlin na resekátu ve srovnání se standardní resekcí. Metody: Do souboru byli zařazeni pacienti k elektivní resekci pro karcinom kolon. Resekát a sentinelová uzlina odeslány k histopatologickému zpracování. Srovnání s kontrolním souborem elektivních resekcí z roku 2011. Výsledky: Kontrolní soubor čítal 56 pacientů operovaných elektivně pro karcinom od céka po rektosigmoideum (dle MKN C18-C19). Průměrný počet uzlin na resekátu byl 12,73 (4−27). Do studované skupiny bylo do počátku listopadu 2014 zařazeno celkem 102 pacientů, celkem 29 pacientů bylo vyřazeno pro nedodržení nebo odchylku od grantového protokolu (neoznačení, neodebrání uzliny, pooperační jiná definitivní diagnóza než karcinom, přítomnost jaterních metastáz). Ze zbylých 73 pacientů (46 mužů a 27 žen) bylo po histopatologickém zpracování celkem 24 (17 mužů a 7 žen) pacientů označeno jako pN+, z nich 2 označeni jako pN1c. U zbývajících 22 pacientů byla sentinelová uzlina pozitivní v 8 případech, což odpovídá senzitivitě 36,36 %. Průměrný počet uzlin na resekátu po barvení Patentblau byl 15,97 (3−30). Závěr: Metoda detekce sentinelové uzliny peroparačně je snadná a snadno proveditelná. Hlavním přínosem se pro nízkou senzitivitu jeví zvýšení počtu nalezených uzlin na resekátu. Klíčová slova: sentinelová uzlina − karcinom kolon − peroperační detekce, Introduction: The aim of this paper is to evaluate the results of intraoperative sentinel node detection in colon cancer patients and to compare the number of nodes retrieved per specimen in comparison with standard resection. Methods: Patients undergoing elective colon cancer resection were included in the study. The specimen and the sentinel lymph node were sent for histopathological examination. A group of patients from 2011 who underwent elective resection served as the study control. Results: The control group comprised 56 patients. The average node count was 12.73 (4–27). The study group included 102 patients; 29 patients had to be excluded because of protocol deviation. Out of the remaining 73 (46 male and 27 female) patients, 24 were N-positive and 2 of them were pN1c. In the remaining 22 patients, the sentinel node was positive in 8 cases, corresponding to a sensitivity of 36.36%. The average lymph node count was 15.97(3–30) after patent blue dye injection. Conclusion: Intraoperative sentinel lymph node detection is an easy and feasible method. Despite the low sensitivity, the main positive effect of the method is the increased lymph node count per resection specimen. Key words: sentinel node − colon cancer − intraoperative detection, and J. Cagaš, I. Čapov, P. Vlček, J. Korbička, L. Veverková, M. Hermanová, M. Tichý
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
29029. Peroperační verifikace integrity kolorektální anastomózy
- Creator:
- Martínek, Lubomír, Bergamaschi, R., and Hoch, Jiří
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, and TEXT
- Subject:
- peroperační péče--metody--využití, anastomóza chirurgická--metody--využití, pooperační komplikace--prevence a kontrola, hojení ran, blízká infračervená spektroskopie--metody--využití, fluoresceinová angiografie--metody--využití, multicentrické studie jako téma, výsledek terapie, and lidé
- Language:
- Czech and English
- Description:
- Časné pooperační komplikace hojení anastomózy představují pro pacienta významné riziko zvýšení morbidity, mortality i zhoršení dlouhodobých výsledků. Existuje řada opatření redukujících rizika vzniku těchto komplikací včetně peroperačního hodnocení kvality kolorektální anastomózy. Postupy hodnocení spolehlivosti anastomózy se vyvíjely od mechanického testování přes endoskopickou vizualizaci střevního lumen až po moderní techniky hodnotící mikroperfuzi perianastomotických tkání. Mechanické testování kolorektální anastomózy a částečně i endoskopické techniky prokazatelně do jisté míry redukují riziko pooperačních komplikací hojení kolorektální anastomózy. Moderní postupy hodnotící mikrocirkulaci, založené na fluorescenční angiografii pomocí indocyaninové zeleně, mají potenciál zásadně zlepšit posouzení bezpečnosti kolorektální anastomózy a významně přispět k rozhodnutí o dalším postupu včetně vynechání protektivní ileostomie., Early postoperative anastomotic complications have serious clinical implications for the patient’s morbidity, mortality as well as long-term results. A number of measures can be undertaken to reduce the risk of anastomotic complications, including intraoperative colorectal anastomotic integrity assessment. Methods used to assess anastomotic reliability have gradually developed from basic mechanical techniques, direct visual endoluminal inspection, to microperfusion assessment of perianastomotic tissue. Moderate benefit in terms of reduced postoperative anastomotic complications has been shown with mechanical patency testing and partly with intraoperative endoscopic visualization of colorectal anastomoses. More recently, indocyanine green (ICG) fluorescence imaging methods have emerged as major contributions to anastomotic patency assessment and intraoperative decision making during surgical colorectal procedures including decreased numbers of ileostomies., and L. Martínek, R. Bergamaschi, J. Hoch
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public
29030. Perorální endoskopická myotomie (POEM) – nová endoskopická možnost léčby achalázie jícnu
- Creator:
- Martínek, Jan, Švecová, H., Špičák, Julius, Krajčíová, Jana, Vacková, Zuzana, Pazdro, Alexandr, Haruštiak, Tomáš, Kieslichová, Eva, Janoušek, Radim, Doležel, Radek, and Fremundová, Lucie
- Format:
- print, text, and regular print
- Type:
- model:article, article, Text, práce podpořená grantem, and TEXT
- Subject:
- achalázie jícnu--terapie, endoskopické operace přirozenými otvory--metody--škodlivé účinky--využití, dolní jícnový svěrač--patofyziologie, stupeň závažnosti nemoci, postup, laparoskopie, and lidé
- Language:
- Czech and English
- Description:
- Perorální endoskopická myotomie (POEM) je slibnou, účinnou a bezpečnou metodou léčby achalázie jícnu a je jen otázkou času, kdy se stane metodou rutinní či ověřenou. Otázka srovnání s laparoskopickou myotomií a balonovou dilatací je klíčová a probíhají randomizované studie. POEM, vzhledem ke komplexní náročnosti a riziku komplikací a vzhledem k řídkému výskytu achalázie jícnu, by měl být soustředěn do maximálně dvou center v České republice. Aktuálně jsme v IKEM provedli 47 výkonů u 46 pacientů s příznivými výsledky., POEM is a promising, effective and safe method of oesophageal achalasia treatment. It is likely that POEM will become a standard and verified treatment option for achalasia. Randomized studies comparing POEM to laparoscopic myotomy or balloon dilatation are crucial and are ongoing. Since POEM is a complex and difficult procedure with a considerable risk of complications, and in view of the quite rare incidence of achalasia, it should be centralized to a maximum of two centres in the Czech Republic. In IKEM, we have performed 47 POEM procedures in 46 patients with excellent results., and Martínek J., Švecová H., Špičák J., Krajčíová J., Vacková Z., Pazdro A., Haruštiak T., Kieslichová E., Janoušek R., Doležel R., Fremundová L.
- Rights:
- http://creativecommons.org/publicdomain/mark/1.0/ and policy:public