One crucial step in the construction of the human representation of the world is found at the boundary between two basic stimuli: visual experience and the sounds of language. In the developmental stage when the ability of recognizing objects consolidates, and that of segmenting streams of sounds into familiar chunks emerges, the mind gradually grasps the idea that utterances are related to the visible entities of the world. The model presented here is an attempt to reproduce this process, in its basic form, simulating the visual and auditory pathways, and a portion of the prefrontal cortex putatively responsible for more abstract representations of object classes. Simulations have been performed with the model, using a set of images of 100 real world objects seen from many different viewpoints and waveforms of labels of various classes of objects. Subsequently, categorization processes with and without language are also compared.
Elevated levels of eukaryotic initiation factor 4E (eIF4E) are implicated in neoplasia, with cumulative evidence pointing to its role in the etiopathogenesis of hematological diseases. As a node of convergence for several oncogenic signaling pathways, eIF4E has attracted a great deal of interest from biologists and clinicians whose efforts have been targeting this translation factor and its biological circuits in the battle against leukemia. The role of eIF4E in myeloid leukemia has been ascertained and drugs targeting its functions have found their place in clinical trials. Little is known, however, about the pertinence of eIF4E to the biology of lymphocytic leukemia and a paucity of literature is available in this regard that prospectively evaluates the topic to guide practice in hematological cancer. A comprehensive analysis on the significance of eIF4E translation factor in the clinical picture of leukemia arises, therefore, as a compelling need. This review presents aspects of eIF4E involvement in the realm of the lymphoblastic leukemia status; translational control of immunological function via eIF4E and the state-of-the-art in drugs will also be outlined., V. Venturi, T. Masek, M. Pospisek., and Obsahuje bibliografii
Let $X$ be a quasicomplete locally convex Hausdorff space. Let $T$ be a locally compact Hausdorff space and let $C_0(T) = \lbrace f\: T \rightarrow I$, $f$ is continuous and vanishes at infinity$\rbrace $ be endowed with the supremum norm. Starting with the Borel extension theorem for $X$-valued $\sigma $-additive Baire measures on $T$, an alternative proof is given to obtain all the characterizations given in [13] for a continuous linear map $u\: C_0(T) \rightarrow X$ to be weakly compact.
We consider inhomogeneous matrix products over max-plus algebra, where the matrices in the product satisfy certain assumptions under which the matrix products of sufficient length are rank-one, as it was shown in [6] (Shue, Anderson, Dey 1998). We establish a bound on the transient after which any product of matrices whose length exceeds that bound becomes rank-one.
Let $G$ be a graph with vertex set $V(G)$, and let $k\ge 1$ be an integer. A subset $D \subseteq V(G)$ is called a {\it $k$-dominating set} if every vertex $v\in V(G)-D$ has at least $k$ neighbors in $D$. The $k$-domination number $\gamma _k(G)$ of $G$ is the minimum cardinality of a $k$-dominating set in $G$. If $G$ is a graph with minimum degree $\delta (G)\ge k+1$, then we prove that $$\gamma _{k+1}(G)\le \frac {|V(G)|+\gamma _k(G)}2.$$ In addition, we present a characterization of a special class of graphs attaining equality in this inequality.