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Start Over Creator Josef Syka

2. Centrum translační biomedicíny v Terezíně a Litoměřicích

Creator:
Eva Syková and Josef Syka
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Věda. Všeobecnosti. Základy vědy a kultury. Vědecká práce, Ústav experimentální medicíny (Akademie věd ČR), výzkum a vývoj, biomedicína, regenerační medicína, research and development, biomedicine, regenerative medicine, 12, and 00
Language:
Czech
Description:
Eva Syková, Josef Syka.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

4. České neurovědy vynikají výzkumem i aplikacemi

Creator:
Josef Syka
Format:
print
Type:
article, zprávy, model:article, and TEXT
Subject:
Věda. Všeobecnosti. Základy vědy a kultury. Vědecká práce, mozek, neurovědy, konference, brain, neurosciences, conferences, 12, and 00
Language:
Czech
Description:
During the Brain Awareness Week, held worldwide annually in March, neuroscientists and other brain scientists acquaint the wider public concerning their research activities and their achievements to advance awareness about the progress and benefits of brain research. Brain Awareness Week was created in the USA by the Dana Alliance for Brain Initiatives in 1996. The thirteenth year of the Brain Awareness Week in the Czech Republic occurred on March 14, 2011. Events were held in the building of the Academy of Sciences of the Czech Republic. and Josef Syka.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

5. Changes in neuronal activity of the inferior colliculus in rat after temporal inactivation of the auditory cortex

Creator:
Jiří Popelář, Nwabueze-Ogbo, F. C., and Josef Syka
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, neurony, neurons, inferior colliculus, auditory cortex, functional ablation, descending pathway, 14, and 612
Language:
English
Description:
The role of cortico-tectal pathways in auditory signal processing was studied in anesthetized rats by comparing the extracellular single unit activity in the inferior colliculus (IC) before and after functional ablation of the auditory cortex (AC) by tetrodotoxin (TTX). The responses of several IC neurons to sound stimuli were simultaneously recorded with a 16-channel electrode probe introduced into the IC. Click-evoked middle latency responses (MLR) recorded from the AC were suppressed for several hours after TTX injection. During AC inactivation the firing rate of IC neurons increased (40 % of neurons), decreased (44 %) or did not change (16 %) in comparison with control conditions. In several IC neurons, TTX injection resulted in alterations in the shape of the rate-level functions. Response thresholds, tuning properties and the type of discharge pattern of IC neurons were not altered during AC inactivation. However, in one-third of the neurons, the initial part of the response was less altered than the later, sustained part. In two-thirds of neuronal pairs, functional decortication resulted in a change in the cross-correlation coefficient. The results reveal the complex changes that appear in IC neuronal activity after functional ablation of the ipsilateral auditory cortex., J. Popelář, F. C. Nwabueze-Ogbo, J. Syka., and Obsahuje bibliografii
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

6. Coding of communication calls in the subcortical and cortical structures of the auditory system

Creator:
Daniel Šuta, Jiří Popelář, and Josef Syka
Format:
print, bez média, and svazek
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, neurofyziologie, neurovědy, sluch, neurophysiology, neuroscientists, hearing, vocalization, guinea pig, inferior colliculus, medial geniculate body, auditory cortex, 14, and 612
Language:
English
Description:
The processing of species-specific communication signals in the auditory system represents an important aspect of animal behavior and is crucial for its social interactions, reproduction, and survival. In this article the neuronal mechanisms underlying the processing of communication signals in the higher centers of the auditory system - inferior colliculus (IC), medial geniculate body (MGB) and auditory cortex (AC) - are reviewed, with particular attention to the guinea pig. The selectivity of neuronal responses for individual calls in these auditory centers in the guinea pig is usually low - most neurons respond to calls as well as to artificial sounds; the coding of complex sounds in the central auditory nuclei is apparently based on the representation of temporal and spectral features of acoustical stimuli in neural networks. Neuronal response patterns in the IC reliably match the sound envelope for calls characterized by one or more short impulses, but do not exactly fit the envelope for long calls. Also, the main spectral peaks are represented by neuronal firing rates in the IC. In comparison to the IC, response patterns in the MGB and AC demonstrate a less precise representation of the sound envelope, especially in the case of longer calls. The spectral representation is worse in the case of low-frequency calls, but not in the case of broad-band ca lls. The emotional content of the call may influence neuronal responses in the auditory pathway, which can be demonstrated by stimulation with time-reversed calls or by measurements performed under different levels of anesthesia. The investigation of the principles of the neural coding of species-specific vocalizations offers some keys for understanding the neural mechanisms underlying human speech perception., D. Šuta, J. Popelář, J. Syka., and Obsahuje bibliografii a bibliografické odkazy
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public

7. Financování základního výzkumu

Creator:
Marina Hužvárová and Josef Syka
Format:
print, bez média, and svazek
Type:
article, rozhovory, model:article, and TEXT
Subject:
Věda. Všeobecnosti. Základy vědy a kultury. Vědecká práce, Grantová agentura České republiky, výzkum a vývoj, financování programů a projektů, granty, research and development, project financing, grants-in-aid, 12, and 00
Language:
Czech
Description:
Marina Hužvárová.
Rights:
http://creativecommons.org/publicdomain/mark/1.0/ and policy:public

8. Hearing function in heterozygous carriers of a pathogenic GJB2 gene mutation

Creator:
Daniel Groh, Pavel Seeman, Jilek, M., Jiří Popelář, Zdeněk Kabelka, and Josef Syka
Type:
article, články, model:article, and TEXT
Subject:
Fyziologie člověka a srovnávací fyziologie, fyziologie člověka, human physiology, c.35delG mutation, audiogram normalization, high-frequency audiometry, otoacoustic emissions, high-frequency hearing loss, 14, and 612
Language:
English
Description:
The most frequent hereditary hearing loss is caused by mutations in the GJB2 gene coding for the gap junction beta 2 protein Connexin 26 (Cx26). In contrast to many studies performed in patients with bi-allelic mutations, audiometric studies on heterozygotes are sparse and often contradictory. To evaluate hearing function in heterozygous carriers of the GJB2 c.35delG mutation, audiometry over the extended frequency range and the recording of otoacoustic emissions (OAEs), i.e., transient-evoked OAEs (TEOAEs) and distortion product OAEs (DPOAEs), were performed in a group of parents and grandparents of deaf children homozygous for the GJB2 c.35delG mutation. The comparison of audiograms between control and heterozygous subjects was enabled using audiogram normalization for age and sex. Hearing loss, estimated with this procedure, was found to be significantly larger in GJB2 c.35delG heterozygous females in comparison with controls for the frequencies of 8-16 kHz; the deterioration of hearing in heterozygous men in comparison with controls was not statisticaly significant. A comparison of TEOAE responses and DPOAE levels between GJB2 c.35delG heterozygotes and controls did not reveal any significant differences. The results prove the importance of using audiometry over the extended frequency range and audiogram normalization for age and sex to detect minor hearing impairments, even in a relatively small group of subjects of different ages., D. Groh, ... [et al.]., and Obsahuje seznam literatury
Rights:
http://creativecommons.org/licenses/by-nc-sa/4.0/ and policy:public