Association of A1166C polymorphism in AT1 receptor gene with baroreflex sensitivity

Title:

Association of A1166C polymorphism in AT1 receptor gene with baroreflex sensitivity

Creator:

Miroslav Jíra, Eva Závodná, Nataša Honzíková, Zuzana Nováková, Anna Vašků, Lydie Izakovičová Hollá, and Bohumil Fišer

Identifier:

https://cdk.lib.cas.cz/client/handle/uuid:695ba3e3-bd5c-457e-8a06-cf8325d5c65a
uuid:695ba3e3-bd5c-457e-8a06-cf8325d5c65a

Subject:

Fyziologie člověka a srovnávací fyziologie, polymorfismus, polymorphism, baroreflex sensitivity, angiotensin II type 1 receptor, spectral analysis, 14, and 612

Type:

article, články, model:article, and TEXT

Format:

print

Description:

The aim of this study was to evaluate the association of A1166C polymorphism in angiotensin II type 1 receptor (AT1R) gene with baroreflex sensitivity (BRS in ms/mm Hg; BRSf in mHz/mm Hg) in man. BRS and BRSf were determined by a spectral method in 135 subjects (19-26 years) at a frequency of 0.1 Hz. Genotypes were detected by means of polymerase chain reaction and restriction analysis using enzyme DdeI. We compared BRS and BRSf among genotypes of this polymorphism. The frequency of genotypes of AT1R A1166C polymorphism was: 45.9 % (AA, n=62), 45.9 % (AC, n=62), 8.2 % (CC, n=11). Differences in BRS (p<0.05) and BRSf (p<0.01) among genotypes of this single nucleotide polymorphism were found (Kruskal-Wallis: BRS - AA: 7.9±3.3, AC: 8.6±3.6, CC: 5.9±2.3 ms/mm Hg; BRSf - AA: 12.0±4.0, AC: 12.0±5.0, CC: 8.0±3.0 mHz/mm Hg). Compared to carriers of other genotypes (AA+AC) the homozygotes with the less frequent allele (CC) showed significantly lower BRSf (Mann-Whitney: BRSf - AA+AC: 12.0±4.0, CC: 8.0±3.0 mHz/mm Hg; p<0.01) and borderline lower BRS (BRS - AA+AC: 8.2±3.5, CC: 5.9±2.5 ms/mm Hg; p=0.07). We found a significant association of A1166C polymorphism in AT1 receptor gene with baroreflex sensitivity. Homozygosity for the less frequent allele was associated with decreased baroreflex sensitivity., M. Jíra ... [et al.]., and Obsahuje bibliografii a bibliografické odkazy

Language:

English

Rights:

http://creativecommons.org/licenses/by-nc-sa/4.0/
policy:public

Source:

Physiological research | 2010 Volume:59 | Number:4

Harvested from:

CDK

Metadata only:

false